Description
- K-stage design
- What is the goal for Simon’s two-stage design? (10%)
- What is the null and alternative hypothesis for Simon’s two-stage design? (10%)
- How do you determine the sample size for Simon’s two-stage design? (10%)
- What is the difference between minmax and optimal design for Simon’s two-stage procedure? (10%)
- What are the draw backs for Simon’s two-stage design? (10%)
- How can you overcome the drawbacks? (10%)
- Write the statistical section of a protocol for a non-superiority trial comparing a testing drug to an placebo control using a continuous outcome.
Be sure you specify:
- The type I and Type II errors
- The superior threshold D
- The rationale for your choice of 1 and 2
- The test statistic you will be using
- The sample size for the trial given the information above
- The interpretation of your findings (i.e., what do you conclude if you reject/not reject the null hypothesis)